In recent years, Can Tho, An Giang and Bac Lieu have a fast pace of tourism development, the growth rate in the number of tourists and tourism turnover increase every year. On the other hand, three provinces are also constantly developing plans and projects on tourism development; paying attention to the construction of new and distinctive tourism products; investing in infrastructure for tourism as well as improving the quality and diversity of tourism services. However, the tourism development of each province is still facing many difficulties. The operating cost is still low and inadequate to the tourism potential and strengths of each province. On this basis, the connection between the three provinces is essential. This close relation not only helps promote special products of each place, but also boosts the service of travel agencies, tourism business in three provinces. It also expands the network of promotion, marketing and formation of a diverse and full-of-experience tour system and tourist routes in order to attract tourists to each province. Through discussions and exchanges of information, the cooperation will be developed by the specialized departments of Can Tho, An Giang and Bac Lieu to establish a general agreement on long-term development cooperation and clarify the tasks, missions, key activities need to be carried out in 2019 and in the long-term development.